An understanding of development necessitates an understanding of the molecular mechanisms of cell typespecific gene expression. Using synthetic promoter constructions, it has been found that 2 sequences within immunoglobulin promoters are sufficient for lymphoidspecific promoter activity: an pou domain class 2 transcription factor 2 A novel POUdomain protein, retinaderived POUdomain factor1 (RPF1), has been identified through the isolation of cDNA and genomic DNA clones.
POU6F2 is a member of a gene family characterized by the presence of a bipartite DNAbinding domain, consisting of a POUspecific domain and a POU heterodomain, separated by a variable polylinker. POU domain family members are transcriptional regulators, many of which show highly restricted patterns pou domain class 2 transcription factor 2
Regulates transcription in a number of tissues in addition to activating immunoglobulin gene expression. Modulates transcription transactivation by NR3C1, AR and PGR. Isoform 5 activates the U2 small nuclear RNA (snRNA) promoter. The protein encoded by this gene is a homeoboxcontaining transcription factor of the POU domain family. POU domain, class 2, transcription factor 1. Alternative name(s): NFA1. Octamerbinding protein 1. Short name: Oct1. Octamerbinding transcription factor 1. POU4F2 is a member of the POUdomain family of transcription factors. POUdomain proteins have been observed to play important roles in control of cell identity in several systems. A class IV POUdomain protein, POU4F2 is found in human retina exclusively within a subpopulation of ganglion cells where it may play a role in determining or maintaining the identities of a small subset of visual pou domain class 2 transcription factor 2 This gene encodes a member of the POU domain family of transcription factors. POU domain transcription factors bind to a specific octamer DNA motif and regulate cell typespecific differentiation pathways. The encoded protein is primarily expressed in the epidermis, and plays a critical role in keratinocyte proliferation and differentiation. Chicken POU Domain, Class 2, Transcription Factor 1 (POU2F1 OCT1) ELISA Kit from ABBEXA Search, find, compare suppliers for Chicken POU Domain, Class 2, Transcription Factor 1 (POU2F1 OCT1) ELISA Kit products. Pou2f2 POU domain, class 2, transcription factor 2 [ (house mouse) Gene ID: , updated on 31Oct2016. Summary Other designations. POU domain, class 2, transcription factor 2, lymphoidrestricted immunoglobulin octamerbinding protein NFA2, octamerbinding POU proteins are eukaryotic transcription factors containing a bipartite DNA binding domain referred to as the POU domain. The acronym POU (pronounced 'pow') is derived from the names of three transcription factors, the pituitaryspecific Pit1, the octamerbinding proteins Oct1 and Oct2, and the neural Unc86 from Caenorhabditis elegans.