How can the answer be improved? class switch recombination mechanism Classswitch recombination (CSR) of immunoglobulin heavy chains is the genetic process by which a B cell switches from the production of IgM to the production of IgG, IgE or IgA.
In LSG of IgG4RD, increased Treg cytokines (IL10 and TGF) might play important roles in IgG4specific class switch recombination and fibrosis, which are characteristic features of IgG4RD. High expression of AID could also contribute to upregulation of IgG4specific class switch recombination along with IL10 in LSG of IgG4RD. class switch recombination mechanism
Immunoglobulin class switching, also known as isotype switching, isotypic commutation or classswitch recombination (CSR), is a biological mechanism that changes a B cell's production of immunoglobulin from one type to another, such as from the isotype IgM to the isotype IgG. Classswitch recombination (CSR) occurs by an unusual and intriguing mechanism that has not been clearly elucidated as yet. Currently, we know that this mechanism involves recombination between large and highly repetitive switch (S) regions, is targeted by Sregion transcription and requires the activity of the newly discovered activationinduced deaminase (AID). Class switch recombination (CSR) occurs between switch (S) regions located upstream of each of the C H regions except C and results in a change from IgM and IgD expression by naive B cells to expression of one of the downstream isotypes. IgD expression occurs by alternative transcription terminationsplicing of the CC genes. class switch recombination mechanism Dec 01, 2014 Class switch recombination (CSR) is instigated by activationinduced cytidine deaminase (AID), which converts cytosines in S regions to uracils. The uracils are subsequently removed by two DNA repair pathways, resulting in mutations, singlestrand DNA breaks, and the doublestrand breaks required for CSR.