IgG protein is comprised of molecules of 4 subclasses designated IgG1 through IgG4. Each subclass contains molecules with a structurally unique gamma heavy chain. Of total IgG, approximately 65 is IgG1, 25 is IgG2, 6 is IgG3, and 4 is IgG4. igg subclass lab values IgG Subclass Immune Deficiency The main immunoglobulin (Ig) in human blood is IgG. This is the second most abundant circulating protein and contains longterm protective antibodies against many infectious agents.
Jul 01, 2013 Description. Quantitative immunoglobulins testing is used to measure levels of the 3 major immunoglobulin classesIgG, IgA, and IgMwhich make up 80, 15, and 5, respectively, of normal serum immunoglobulins. igg subclass lab values
Serum IgG levels are usually less than 200 mgdL, and IgM and IgA levels are less than 20 mgdL. Peripheral blood CD19 Bcell counts are commonly less than 0. 1. Patients with one of the hyperIgM syndromes, Xlinked or autosomal recessive, have a deficiency of IgG and IgA. Performing Laboratory Mayo Clinic Laboratories in Rochester Specimen Type Serum Reference Values. TOTAL IgG. 05 months: mgdL. 59 months: mgdL. Diminished concentrations of all immunoglobulin G (IgG) subclasses are found in common variable immunodeficiency, combined immunodeficiency, ataxia telangiectasia, and other Testing includes total immunoglobulin G (IgG) as well as the 4 subclasses of IgG. Website Feedback Portions 2019 Mayo Foundation for Medical Education and Research. igg subclass lab values Diagnosis of IgG Subclass Deficiency. Its important to remember that the definition of normal IgG subclass concentrations varies over time, and from lab to lab. Normal values usually represent a small range below and above the average for a persons age. An